Although the opiate receptor relies on G protein coupling for sign transduction, this receptor was located to make the most of arrestin activation for internalization with the receptor. Or else, the receptor promoted no other signaling cascades (59) Modifications of conolidine have resulted in variable advancement in binding efficacy. https://spencerjprsr.mpeblog.com/67616891/5-simple-statements-about-conolidin-to-replace-traditional-painkillers-explained