Pentobarbital will lower the extent or result of midostaurin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Prevent or Use Alternate Drug. Sturdy CYP3A4 inducers could decrease midostaurin concentrations leading to lowered efficacy. pentobarbital will lower the extent or influence of theophylline by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep tra... https://miriamm654zpd1.wikiexpression.com/user