Environmental or self-antigens and homotypic interactions induce BCR and Toll-like receptor (TLR) signaling, amplifying the response of CLL cells to other alerts within the microenvironment and rising the activation of anti-apoptotic and proliferation pathways.31,32 Genomic reports have determined recurrent mutations in genes regulating tumor cell-microenvironment interactions, that a... https://georgec075vel2.fare-blog.com/profile