Even though the opiate receptor depends on G protein coupling for sign transduction, this receptor was identified to make use of arrestin activation for internalization with the receptor. Otherwise, the receptor promoted no other signaling cascades (fifty nine) Modifications of conolidine have resulted in variable improvement in binding efficacy. https://johnnyboxcg.shotblogs.com/5-simple-statements-about-bennifits-of-conolidine-explained-43473946