DNA ligases seal five′-PO4 and three′-OH polynucleotide finishes by means of a few nucleotidyl transfer actions involving ligase-adenylate and DNA-adenylate intermediates. DNA ligases are important guardians of genomic integrity, and ligase dysfunction underlies human genetic ailment syndromes. Crystal structures of DNA ligases bound to nucleotide and nucleic acid substrates https://stephenn245iez2.governor-wiki.com/user